|
Hgh Human Growth Hormone Dosage
Administration
For subcutaneous injection.
Therapy with Humatrope should be supervised
by a physician who is experienced in the
diagnosis and management of pediatric
patients with short stature associated with
GH deficiency, Turner syndrome, idiopathic
short stature, SHOX deficiency, small for
gestational age birth, or adult patients
with either childhood-onset or adult-onset
GH deficiency.
Reconstitution
Vial — Each 5-mg vial of
Humatrope should be reconstituted with 1.5
to 5 mL of Diluent for Humatrope. The
diluent should be injected into the vial of
Humatrope by aiming the stream of liquid
gently against the vial wall. Following
reconstitution, the vial should be swirled
with a GENTLE rotary motion until the
contents are completely dissolved. DO NOT
SHAKE. The resulting solution should be
clear. If the solution is cloudy or
contains particulate matter, the contents
MUST NOT be injected.
If sensitivity to the diluent should occur,
the vials may be reconstituted with
Bacteriostatic Water for Injection (Benzyl
Alcohol preserved), USP or Sterile Water
for Injection, USP. When Humatrope is
reconstituted with Bacteriostatic Water for
Injection, USP, the solution should be kept
refrigerated at 36° to 46°F (2° to 8°C) and
used within 14 days. It is important to
note that benzyl alcohol used as a
preservative in Bacteriostatic Water has
been associated with toxicity in newborns.
Therefore, Bacteriostatic Water for
Injection must not be used to reconstitute
Humatrope for use in a newborn infant. When
Humatrope is to be administered to a
newborn infant it should be reconstituted
with the diluent provided or, if the infant
is sensitive to the diluent, Sterile Water
for Injection, USP.. When reconstituted
with Sterile Water for Injection the
solution should be kept refrigerated at 36°
to 46°F (2° to 8°C) and used within 24
hours.
General Administration Guidelines
For all indications, the following general
principles for administration should be
followed:
- When using the Humatrope vial the
septum of the vial should be wiped with an
alcoholic antiseptic solution before and
after each injection to prevent
contamination of the contents by repeated
needle insertions. Sterile disposable
syringes and needles should be used. The
volume of the syringe should be small
enough so that the prescribed dose can be
withdrawn from the vial with reasonable
accuracy.
- When using the Humatrope cartridge a
sterile disposable needle should be used
for each injection.
- Humatrope should be administered by
subcutaneous injection with regular
rotation of injection sites to avoid
lipoatrophy.
- For pediatric patients the calculated
weekly Humatrope dosage should be divided
into equal doses given either 6 or 7 days
per week.
- For adult patients the prescribed dose
should be administered daily.
|
